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Tramadol Generic
Tramadol has been used in clinical practice for a long time to relieve moderate to severe pain.Tramadol is an opiate receptor agonist, interacting primarily with the m-subtype, and also inhibits the reuptake of some monoamines (norepinephrine, serotonin), which contributes to the development of an analgesic effect. The active metabolite of tramadol, o-demethyltramadol, significantly exceeds the original substance in affinity for m-opioid receptors and in analgesic activity - 2-4 times. The antinociceptive effect of tramadol is partially eliminated by the opiate receptor antagonist naloxone.
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Drug Name: Tramadol (Ultram)
Tablet Strength: 180 pills x 100mg
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Drug Dosage
Tramadol is not an opium derivative or a semi-synthetic derivative of morphine or thebaine, although its analgesic effect is due to agonism in relation to opiate receptors. Contraindications
Tramadol treatment may cause dependence and withdrawal symptoms, but the latter is less pronounced than with other opiate receptor agonists, as well as side effects - nausea, lethargy, constipation, dry mouth, increased sweating, and itching. Respiratory depression is usually not pronounced compared to morphine but may be observed when using the drug in high doses. In this regard, Tramadol is prescribed with caution to patients at risk of developing respiratory depression. Side effects are usually rare; from the cardiovascular system, arterial hypotension, syncope, and sinus tachycardia may develop.
How to use
Tramadol 100mg is widely used to relieve acute and chronic pain of moderate and severe intensity of various etiologies in patients after various surgical interventions, including orthopedic, gynecological operations, cesarean section, dental surgical procedures (e.g., extraction of molars).
When administered parenterally in a daily dose of 100-250 mg (lumbago, neuropathy, musculoskeletal diseases, as well as when used in maxillofacial surgery), the drug is not inferior in effectiveness to repeated use of combined analgesics for oral administration, including those containing codeine.
Tramadol Online is indicated for pain syndrome in patients with oncological diseases with insufficient effectiveness of non-narcotic analgesics. The drug is inferior in effectiveness to morphine derivatives but significantly less often causes the development of serious side effects.
Tramadol is also used to eliminate severe myalgia in leptospirosis, pain syndrome in enterovirus infections, colitis of infectious etiology.
Generic Tramadol is prescribed in a dose of 50-100 mg subcutaneously, intramuscularly or intravenously (slowly). The maximum analgesic effect develops approximately within 1 hour after administration of the drug, its duration is 3-6 hours. If necessary, re-administer at a dose of 50 mg after 30-60 minutes.
Side effects
urination disorders.
Possible overdose
The drug should be used with caution simultaneously with carbamazepine, opiate analgesics - it is possible to potentiate the side effects characteristic of these drugs.
The drug may have an adverse effect on the ability to drive vehicles and potentially dangerous mechanisms. When using the drug, alcohol should be avoided. During pregnancy, it is used only in cases where the expected benefit to the expectant mother outweighs the potential risk to the fetus.
Tramadol is excreted in breast milk. There is no data on the safety of its use during breastfeeding.Clinical manifestations of an overdose of the drug are similar to those of opiate poisoning - miosis, vomiting, respiratory depression, convulsions, collapse.
In such cases, supportive treatment is carried out, aimed primarily at ensuring adequate respiratory function (artificial ventilation). Naloxone (an opiate antagonist) eliminates some of the effects of Tramadol. The effectiveness of hemodialysis is low.
If the recommendations for use are followed, Tramadol 100mg is an effective and safe analgesic in the treatment of pain syndrome of various origins.